Biochem/physiol Actions

Primary Target5-HT uptake transporter

General description

A very potent uptake inhibitor highly selective for serotonin (K_i = 3.3 nM). Clinically prescribed as an antidepressant drug. Often used in studying major depressive disorders.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Brunoni, R., et al. 2013. JAMA Psychiatry.70, 383.r>Kobayashi, K., et al. 1995. Br. J. Clin. Pharmacol.40, 481.Heym, J., et al. 1988. J. Clin. Psychiatry.49 Suppl, 40.Koe, K., et al. 1983. J. Pharmacol. Exp. Ther.226, 700.

Packaging

10 mg in Glass bottle

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Standard Handling (A)